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ASSOCIATION OF APOLIPOPROTEINS AND APOLIPOPROTEIN SUBSPECIES WITH HIPPOCAMPAL AND WHITE MATTER LESION VOLUME

      Apolipoproteins characterize a heterogeneous group of lipoproteins found in the brain and circulation that facilitate the transport of hydrophobic compounds through aqueous fluids. We sought to determine whether apolipoproteins previously implicated in Alzheimer’s disease are associated with hippocampal volume and white matter lesion volume. Further, we examined whether subspecies of apolipoproteins, based on the presence or absence of other apolipoproteins, provide information about Alzheimer’s pathophysiology beyond their overall concentrations.
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