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Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

  • Erika Ogino
    Affiliations
    Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA
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  • Jennifer J. Manly
    Affiliations
    Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA

    Department of Neurology, Columbia University, New York, NY, USA

    Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
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  • Nicole Schupf
    Affiliations
    Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA

    Department of Neurology, Columbia University, New York, NY, USA

    Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA
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  • Richard Mayeux
    Affiliations
    Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA

    Department of Neurology, Columbia University, New York, NY, USA

    Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA

    Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA
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  • Yian Gu
    Correspondence
    Corresponding author. Tel.: 212-305-6684; Fax: 212-342-1838.
    Affiliations
    Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA

    Department of Neurology, Columbia University, New York, NY, USA

    Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA

    Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA
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Published:October 03, 2019DOI:https://doi.org/10.1016/j.jalz.2019.07.013

      Highlights

      • More current and earlier-life LTPA were associated with reduced risk of Alzheimer's disease (AD).
      • Increasing or maintaining high LTPA throughout life was protective against AD.
      • Avoiding being physically inactive throughout life was beneficial for prevention of AD.
      • There was a health benefit in AD prevention by performing light and moderate LTPAs.

      Abstract

      Introduction

      The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study.

      Methods

      The metabolic equivalent of LTPA energy expenditure was calculated for self-reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk.

      Results

      Comparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20–0.75) and 0.37 (0.18–0.75), respectively. Compared with “always low,” “increased” and “always high” LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36–0.99) and 0.28 (0.08–0.94), respectively. Light- and moderate-intensity LTPA were associated with lower AD risk.

      Discussion

      LTPA both throughout life and later in life are associated with lower risk of AD.

      Keywords

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      References

      1. Knapp M, Comas-Herrera A, Guerchet M, Karagiannidou M. The World Alzheimer Report 2016, Improving healthcare for people living with dementia: Coverage, quality and costs now and in the future. London, UK: Alzheimer's Disease International (ADI); September 2016.

        • Fabrigoule C.
        • Letenneur L.
        • Dartigues J.F.
        • Zarrouk M.
        • Commenges D.
        • Barberger-Gateau P.
        Social and leisure activities and risk of dementia: a prospective longitudinal study.
        J Am Geriatr Soc. 1995; 43: 485-490
        • Laurin D.
        • Verreault R.
        • Lindsay J.
        • MacPherson K.
        • Rockwood K.
        Physical activity and risk of cognitive impairment and dementia in elderly persons.
        Arch Neurol. 2001; 58: 498-504
        • Podewils L.J.
        • Guallar E.
        • Kuller L.H.
        • Fried L.P.
        • Lopez O.L.
        • Carlson M.
        • et al.
        Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study.
        Am J Epidemiol. 2005; 161: 639-651
        • Larson E.B.
        • Wang L.
        • Bowen J.D.
        • McCormick W.C.
        • Teri L.
        • Crane P.
        • et al.
        Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older.
        Ann Intern Med. 2006; 144: 73-81
        • Scarmeas N.
        • Luchsinger J.A.
        • Schupf N.
        • Brickman A.M.
        • Cosentino S.
        • Tang M.X.
        • et al.
        Physical activity, diet, and risk of Alzheimer disease.
        JAMA. 2009; 302: 627-637
        • Abbott R.D.
        • White L.R.
        • Ross G.W.
        • Masaki K.H.
        • Curb J.D.
        • Petrovitch H.
        Walking and dementia in physically capable elderly men.
        JAMA. 2004; 292: 1447-1453
        • Taaffe D.R.
        • Irie F.
        • Masaki K.H.
        • Abbott R.D.
        • Petrovitch H.
        • Ross G.W.
        • et al.
        Physical activity, physical function, and incident dementia in elderly men: the Honolulu-Asia Aging Study.
        J Gerontol Ser A Biol Sci Med Sci. 2008; 63: 529-535
        • Ravaglia G.
        • Forti P.
        • Lucicesare A.
        • Pisacane N.
        • Rietti E.
        • Bianchin M.
        • et al.
        Physical activity and dementia risk in the elderly: findings from a prospective Italian study.
        Neurology. 2008; 70: 1786-1794
        • Kim K.W.
        • Park J.H.
        • Kim M.H.
        • Kim M.D.
        • Kim B.J.
        • Kim S.K.
        • et al.
        A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea.
        J Alzheimer's Dis. 2011; 23: 281-291
        • Gureje O.
        • Oladeji B.
        • Abiona T.
        Incidence and risk factors for late-life depression in the Ibadan Study of Ageing.
        Psychol Med. 2011; 41: 1897-1906
        • Buchman A.S.
        • Boyle P.A.
        • Yu L.
        • Shah R.C.
        • Wilson R.S.
        • Bennett D.A.
        Total daily physical activity and the risk of AD and cognitive decline in older adults.
        Neurology. 2012; 78: 1323-1329
        • Verdelho A.
        • Madureira S.
        • Ferro J.M.
        • Baezner H.
        • Blahak C.
        • Poggesi A.
        • et al.
        Physical activity prevents progression for cognitive impairment and vascular dementia: results from the LADIS (Leukoaraiosis and Disability) study.
        Stroke. 2012; 43: 3331-3335
        • Bowen M.E.
        A prospective examination of the relationship between physical activity and dementia risk in later life.
        Am J Health Promot. 2012; 26: 333-340
        • de Bruijn R.F.
        • Schrijvers E.M.
        • de Groot K.A.
        • Witteman J.C.
        • Hofman A.
        • Franco O.H.
        • et al.
        The association between physical activity and dementia in an elderly population: the Rotterdam Study.
        Eur J Epidemiol. 2013; 28: 277-283
        • Wang S.
        • Luo X.
        • Barnes D.
        • Sano M.
        • Yaffe K.
        Physical activity and risk of cognitive impairment among oldest-old women.
        Am J Geriatr Psychiatry. 2014; 22: 1149-1157
        • Kishimoto H.
        • Ohara T.
        • Hata J.
        • Ninomiya T.
        • Yoshida D.
        • Mukai N.
        • et al.
        The long-term association between physical activity and risk of dementia in the community: the Hisayama Study.
        Eur J Epidemiol. 2016; 31: 267-274
        • Zhou Z.
        • Fu J.
        • Hong Y.A.
        • Wang P.
        • Fang Y.
        Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.
        BMJ Open. 2017; 7: e017497
        • Llamas-Velasco S.
        • Contador I.
        • Villarejo-Galende A.
        • Lora-Pablos D.
        • Bermejo-Pareja F.
        Physical activity as protective factor against dementia: a prospective Population-Based Study (NEDICES).
        J Int Neuropsychological Soc. 2015; 21: 861-867
        • Andel R.
        • Crowe M.
        • Pedersen N.L.
        • Fratiglioni L.
        • Johansson B.
        • Gatz M.
        Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins.
        J Gerontol Ser A Biol Sci Med Sci. 2008; 63: 62-66
        • Etgen T.
        • Sander D.
        • Huntgeburth U.
        • Poppert H.
        • Forstl H.
        • Bickel H.
        Physical activity and incident cognitive impairment in elderly persons: the INVADE study.
        Arch Intern Med. 2010; 170: 186-193
        • Mehlig K.
        • Skoog I.
        • Waern M.
        • Miao Jonasson J.
        • Lapidus L.
        • Bjorkelund C.
        • et al.
        Physical activity, weight status, diabetes and dementia: a 34-year follow-up of the population study of women in Gothenburg.
        Neuroepidemiology. 2014; 42: 252-259
        • Tolppanen A.M.
        • Solomon A.
        • Kulmala J.
        • Kareholt I.
        • Ngandu T.
        • Rusanen M.
        • et al.
        Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia.
        Alzheimer's Demen. 2015; 11: 434-443.e6
        • Palta P.
        • Sharrett A.R.
        • Deal J.A.
        • Evenson K.R.
        • Gabriel K.P.
        • Folsom A.R.
        • et al.
        Leisure-time physical activity sustained since midlife and preservation of cognitive function: the Atherosclerosis Risk in Communities Study.
        Alzheimer's Dement. 2019; 15: 273-281
        • Middleton L.E.
        • Barnes D.E.
        • Lui L.Y.
        • Yaffe K.
        Physical activity over the life course and its association with cognitive performance and impairment in old age.
        J Am Geriatr Soc. 2010; 58: 1322-1326
        • Broe G.A.
        • Creasey H.
        • Jorm A.F.
        • Bennett H.P.
        • Casey B.
        • Waite L.M.
        • et al.
        Health habits and risk of cognitive impairment and dementia in old age: a prospective study on the effects of exercise, smoking and alcohol consumption.
        Aust New Zealand J Public Health. 1998; 22: 621-623
        • Bae J.B.
        • Kim Y.J.
        • Han J.W.
        • Kim T.H.
        • Park J.H.
        • Lee S.B.
        • et al.
        Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly.
        Dement Geriatr Cogn Disord. 2015; 39: 105-115
        • Verghese J.
        • Lipton R.B.
        • Katz M.J.
        • Hall C.B.
        • Derby C.A.
        • Kuslansky G.
        • et al.
        Leisure activities and the risk of dementia in the elderly.
        New Engl J Med. 2003; 348: 2508-2516
        • Morgan G.S.
        • Gallacher J.
        • Bayer A.
        • Fish M.
        • Ebrahim S.
        • Ben-Shlomo Y.
        Physical activity in middle-age and dementia in later life: findings from a prospective cohort of men in Caerphilly, South Wales and a meta-analysis.
        J Alzheimer's Dis. 2012; 31: 569-580
        • Wilson R.S.
        • Mendes De Leon C.F.
        • Barnes L.L.
        • Schneider J.A.
        • Bienias J.L.
        • Evans D.A.
        • et al.
        Participation in cognitively stimulating activities and risk of incident Alzheimer disease.
        JAMA. 2002; 287: 742-748
        • Akbaraly T.N.
        • Portet F.
        • Fustinoni S.
        • Dartigues J.F.
        • Artero S.
        • Rouaud O.
        • et al.
        Leisure activities and the risk of dementia in the elderly: results from the Three-City Study.
        Neurology. 2009; 73: 854-861
        • Sabia S.
        • Dugravot A.
        • Dartigues J.F.
        • Abell J.
        • Elbaz A.
        • Kivimaki M.
        • et al.
        Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study.
        BMJ. 2017; 357: j2709
        • Taylor H.L.
        • Jacobs Jr., D.R.
        • Schucker B.
        • Knudsen J.
        • Leon A.S.
        • Debacker G.
        A questionnaire for the assessment of leisure time physical activities.
        J Chronic Dis. 1978; 31: 741-755
        • Stern Y.
        • Andrews H.
        • Pittman J.
        • Sano M.
        • Tatemichi T.
        • Lantigua R.
        • et al.
        Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education.
        Arch Neurol. 1992; 49: 453-460
        • McKhann G.
        • Drachman D.
        • Folstein M.
        • Katzman R.
        • Price D.
        • Stadlan E.M.
        Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
        Neurology. 1984; 34: 939-944
        • Petersen R.C.
        • Smith G.E.
        • Waring S.C.
        • Ivnik R.J.
        • Tangalos E.G.
        • Kokmen E.
        Mild cognitive impairment: clinical characterization and outcome.
        Arch Neurol. 1999; 56: 303-308
        • Manly J.J.
        • Tang M.X.
        • Schupf N.
        • Stern Y.
        • Vonsattel J.P.
        • Mayeux R.
        Frequency and course of mild cognitive impairment in a multiethnic community.
        Ann Neurol. 2008; 63: 494-506
        • Godin G.
        • Shephard R.J.
        A simple method to assess exercise behavior in the community.
        Can J Appl Sport Sci. 1985; 10: 141-146
        • Sallis J.F.
        • Buono M.J.
        • Roby J.J.
        • Micale F.G.
        • Nelson J.A.
        Seven-day recall and other physical activity self-reports in children and adolescents.
        Med Sci Sports Exerc. 1993; 25: 99-108
        • Jacobs Jr., D.R.
        • Ainsworth B.E.
        • Hartman T.J.
        • Leon A.S.
        A simultaneous evaluation of 10 commonly used physical activity questionnaires.
        Med Sci Sports Exerc. 1993; 25: 81-91
        • Stern Y.
        • MacKay-Brandt A.
        • Lee S.
        • McKinley P.
        • McIntyre K.
        • Razlighi Q.
        • et al.
        Effect of aerobic exercise on cognition in younger adults: a randomized clinical trial.
        Neurology. 2019; 92: e905-e916
        • Varma V.R.
        • Chuang Y.F.
        • Harris G.C.
        • Tan E.J.
        • Carlson M.C.
        Low-intensity daily walking activity is associated with hippocampal volume in older adults.
        Hippocampus. 2015; 25: 605-615
        • Phillips C.
        • Baktir M.A.
        • Das D.
        • Lin B.
        • Salehi A.
        The link between physical activity and cognitive dysfunction in Alzheimer disease.
        Phys Ther. 2015; 95: 1046-1060
        • Gomez-Pinilla F.
        • Vaynman S.
        • Ying Z.
        Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.
        Eur J Neurosci. 2008; 28: 2278-2287
        • Vaynman S.
        • Ying Z.
        • Gomez-Pinilla F.
        Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.
        Eur J Neurosci. 2004; 20: 2580-2590
        • Kesaniemi Y.K.
        • Danforth Jr., E.
        • Jensen M.D.
        • Kopelman P.G.
        • Lefebvre P.
        • Reeder B.A.
        Dose-response issues concerning physical activity and health: an evidence-based symposium.
        Med Sci Sports Exerc. 2001; 33: S351-S358
        • Adlard P.A.
        • Perreau V.M.
        • Pop V.
        • Cotman C.W.
        Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.
        J Neurosci. 2005; 25: 4217-4221
        • Swain R.A.
        • Harris A.B.
        • Wiener E.C.
        • Dutka M.V.
        • Morris H.D.
        • Theien B.E.
        • et al.
        Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat.
        Neuroscience. 2003; 117: 1037-1046
        • Brown B.M.
        • Peiffer J.J.
        • Taddei K.
        • Lui J.K.
        • Laws S.M.
        • Gupta V.B.
        • et al.
        Physical activity and amyloid-beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing.
        Mol Psychiatry. 2013; 18: 875-881
        • Thompson P.D.
        • Buchner D.
        • Pina I.L.
        • Balady G.J.
        • Williams M.A.
        • Marcus B.H.
        • et al.
        Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity).
        Circulation. 2003; 107: 3109-3116