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Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results

Published:November 18, 2019DOI:https://doi.org/10.1016/j.jalz.2019.08.202

      Abstract

      Introduction

      We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.

      Methods

      Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50–86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging–Alzheimer's Association diagnostic criteria.

      Results

      The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.

      Discussion

      MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.

      Keywords

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      References

        • Census
        American Community Survey.
        (Available at: https://www.census.gov/programs-surveys/acs. Accessed October 11, 2019.)2017
        • Colby S.L.
        • Ortman J.M.
        Projections of the Size and Composition of the US Population: 2014 to 2060. Population Estimates and Projections. Current Population Reports.
        US Census Bureau, 2015: 25-1143
        • Matthews KA
        • Xu W
        • Gaglioti AH
        • Holt JB
        • Croft JB
        • Mack D
        • et al.
        Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015-2060) in adults aged ≥65 years.
        Alzheimers Dement. 2019; 15: 17-24
        • Gurland BJ
        • Wilder DE
        • Lantigua R
        • Stern Y
        • Chen J
        • Killeffer EH
        • et al.
        Rates of dementia in three ethnoracial groups.
        Int J Geriatr Psychiatry. 1999; 14: 481-493
        • Haan M.N.
        • Mungas D.M.
        • González H.M.
        • Ortiz T.A.
        • Acharya A.
        • Jagust W.J.
        Prevalence of dementia in older Latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors.
        J Am Geriatr Soc. 2003; 51: 169-177
        • Conomos MP
        • Laurie CA
        • Stilp AM
        • Gogarten SM
        • McHugh CP
        • Nelson SC
        • et al.
        Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos.
        Am J Hum Genet. 2016; 98: 165-184
        • González HM
        • Tarraf W
        • Rodríguez CJ
        • Gallo LC
        • Sacco RL
        • Talavera GA
        • et al.
        Cardiovascular health among diverse Hispanics/Latinos: Hispanic Community Health Study/Study of Latinos (HCHS/SOL) results.
        Am Heart J. 2016; 176: 134-144
        • Tang MX
        • Stern Y
        • Marder K
        • Bell K
        • Gurland B
        • Lantigua R
        • et al.
        The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.
        JAMA. 1998; 279: 751-755
        • O’Bryant SE
        • Johnson L
        • Reisch J
        • Edwards M
        • Hall J
        • Barber R
        • et al.
        Risk factors for mild cognitive impairment among Mexican Americans.
        Alzheimers Dement. 2013; 9: 622-631.e621
        • Schneiderman N
        • Llabre M
        • Cowie CC
        • Barnhart J
        • Carnethon M
        • Gallo LC
        • et al.
        Prevalence of diabetes among Hispanics/Latinos from diverse backgrounds: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
        Diabetes Care. 2014; 37: 2233-2239
        • Hachinski V
        • Einhäupl K
        • Ganten D
        • Alladi S
        • Brayne
        • Stephan BC
        • et al.
        Preventing dementia by preventing stroke: the Berlin Manifesto.
        Alzheimer’s Dement. 2019; 15: 961-984
        • LaVange LM
        • Kalsbeek WD
        • Sorlie PD
        • Avilés-Santa SM
        • Kaplan RC
        • Barnhart J
        • et al.
        Sample design and cohort selection in the Hispanic Community Health Study/Study of Latinos.
        Ann Epidemiol. 2010; 20: 642-649
        • Sorlie PD
        • Avilés-Santa LM
        • Wassertheil-Smoller S
        • Kaplan RC
        • Daviglus ML
        • Giachello AL
        • et al.
        Design and implementation of the Hispanic Community Health Study/Study of Latinos.
        Ann Epidemiol. 2010; 20: 629-641
        • Callahan C.M.
        • Unverzagt F.W.
        • Hui S.L.
        • Perkins A.J.
        • Hendrie H.C.
        Six-item screener to identify cognitive impairment among potential subjects for clinical research.
        Med Care. 2002; 40: 771-781
        • González H.M.
        • Mungas D.
        • Reed B.R.
        • Marshall S.
        • Haan M.N.
        A new verbal learning and memory test for English- and Spanish-speaking older people.
        J Int Neuropsychol Soc. 2001; 7: 544-555
        • Lezak M
        • Howieson DB
        • Loring DW
        Neuropsychological Assessment.
        Oxford University Press, New York2004: 545-546
        • Wechsler D.
        WAIS-R Manual.
        Psychological Corporation, San Antonio, TX1981
        • Albert MS
        • DeKosky ST
        • Dickson D
        • Dubois B
        • Feldman HH
        • Fox NC
        • et al.
        The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
        Alzheimers Dement. 2011; 7: 270-279
        • Farias ST
        • Mungas D
        • Reed BR
        • Cahn-Weiner D
        • Jagust W
        • Baynes K
        • et al.
        The measurement of everyday cognition (ECog): scale development and psychometric properties.
        Neuropsychology. 2008; 22: 531-544
        • Fillenbaum GG
        Multidimensional Functional Assessment of Older Adults: The Duke Older Americans Resources and Services Procedures.
        Lawrence Erlbaum Associates, Inc., Hillsdale, NJ1988: 7-11
        • Manly J.J.
        • Byrd D.A.
        • Touradji P.
        • Stern Y.
        Acculturation, reading level, and neuropsychological test performance among African American elders.
        Appl Neuropsychol. 2004; 11: 37-46
        • Kannel W.B.
        • McGee D.
        • Gordon T.
        A general cardiovascular risk profile: the Framingham Study.
        Am J Cardiol. 1976; 38: 46-51
        • D’agostino RB
        • Vasan RS
        • Pencina MJ
        • Wolf PA
        • Cobain M
        • Massaro JM
        • et al.
        General cardiovascular risk profile for use in primary care: the Framingham Heart Study.
        Circulation. 2008; 117: 743-753
        • González HM
        • Tarraf W
        • Jian X
        • Vásquez PM
        • Kaplan R
        • Thyagarajan B
        • et al.
        Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL).
        Scientific Rep. 2018; 8: 17578
        • Wassertheil-Smoller S
        • Arredondo EM
        • Cai J
        • Castaneda SF
        • Choca JP
        • Gallo LC
        • et al.
        Depression, anxiety, antidepressant use, and cardiovascular disease among Hispanic men and women of different national backgrounds: results from the Hispanic Community Health Study/Study of Latinos.
        Ann Epidemiol. 2014; 24: 822-830
        • Barnes D.E.
        • Alexopoulos G.S.
        • Lopez O.L.
        • Williamson J.D.
        • Yaffe K.
        Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study.
        JAMA Psychiatry. 2006; 63: 273-279
        • Harrington KD
        • Gould E
        • Lim YY
        • Ames D
        • Pietrzak RH
        • Rembach A
        • et al.
        Amyloid burden and incident depressive symptoms in cognitively normal older adults.
        Int J Geriatr Psychiatry. 2017; 32: 455-463
        • Knopman DS
        • Gottesman RF
        • Sharrett AR
        • Wruck LM
        • Windham BG
        • Coker L
        • et al.
        Mild cognitive impairment and dementia prevalence: the atherosclerosis risk in communities neurocognitive study.
        Alzheimers Dement. 2016; 2: 1-11
        • Vermeer SE
        • Den Heijer T
        • Koudstaal PJ
        • Oudkerk M
        • Hofman A
        • Breteler MM
        Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.
        Stroke. 2003; 34: 392-396
        • Corbo R.M.
        • Scacchi R.
        Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a ‘thrifty’ allele?.
        Ann Hum Genet. 1999; 63: 301-310